Lyme Disease Pathogenesis

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Insight into the Pathogenesis of Lyme Disease

Lyme disease is the most common vector-borne disease in the United States and Europe, caused by a tick-borne spirochete, Borrelia burgdorferi. Life cycle alternation between arthropod and mammals enhanced B. burgdorferi to adapt to two diverse niches. Although B. burgdorferi infection in these reservoir hosts appears asymptomatic, infection in human can typically cause inflammation in the skin,...

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Pathogenesis of post-lyme disease symptoms.

TO THE EDITOR—In an effort to understand the pathogenesis of post-Lyme disease symptoms, the article by Strle et al estimated the levels of 15 cytokines and an additional 11 chemokines in erythema migrans patients from Slovenia [1]. Their finding of elevated levels of the type 17 helper T-cell (T H 17)–associated interleu-kin 23 (IL-23) in some of the patients with persistent symptoms is a valu...

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a case of lyme disease (lyme borreliosis)

while an important infectious disease in the united states and eurasia, lyme disease is rare in iran. we present a 9-year old boy admitted in children’s medical center in december 2001 with final diagnosis of lyme disease. on admission he showed arthritis and a history of previous skin lesions. serologic examination including enzyme–linked immunosorbent assay and western blot was positive for l...

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Bacterial pathogenesis: A variation on variation in Lyme disease

The discovery of antigenic variation in Borrelia burgdorferi, the bacterium that causes Lyme disease, provides a potential explanation for the chronic nature of infection as well as new insights into the genetic structure of highly recombinogenic loci responsible for combinatorial genetic diversification.

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Lyme disease is caused by the spirochete Borrelia burgdorferi. Depending on the stage of illness, infection may be limited to the skin or involve the cardiac, nervous and musculoskeletal systems. Herein, we report a case of Lyme disease in a 23-year-old woman from North of Iran (Mazandaran) in early-localized stage of erythema chronicum migrans. The diagnosis was confirmed by the presence of se...

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ژورنال

عنوان ژورنال: Current Issues in Molecular Biology

سال: 2022

ISSN: 1467-3037

DOI: 10.21775/cimb.042.473